Pre-Eclampsia in Women with Raised C-Reactive Protein Levels Before 20th Week of Gestation; A Cohort Study

ABSTRACT Objective: To assess the association of pre-eclampsia in women with raised CRP before 20 weeks of gestation. Study Design: Prospective cohort study, Place and Duration of Study: Department of Obstetrics and Gynaecology, Civil Hospital, Karachi Pakistan, from Jan to Aug 2019. Methodology: On...

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Published inPakistan Armed Forces medical journal Vol. 74; no. 1; p. 54
Main Authors Memon, Komal, Jabbar, Shazia, Bozdar, Marvi, Sumyya Ahmed, Shahzadi, Younus, Maryam
Format Journal Article
LanguageEnglish
Published Rawalpindi Knowledge Bylanes 29.02.2024
AsiaNet Pakistan (Pvt) Ltd
Army Medical College Rawalpindi
Subjects
Analysis
Blood pressure
Body mass index
C-reactive protein
Cesarean section
Childbirth & labor
Cohort analysis
Data analysis
Development and progression
Gynecology
Hypertension
Immunoassay
Inflammation
Maternal mortality
Mothers
Obstetrics
Parity
Patient outcomes
Pre-eclampsia
Preeclampsia
Pregnancy
Pregnant women
Proteins
Vagina
Womens health
Pakistan
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Summary:ABSTRACT Objective: To assess the association of pre-eclampsia in women with raised CRP before 20 weeks of gestation. Study Design: Prospective cohort study, Place and Duration of Study: Department of Obstetrics and Gynaecology, Civil Hospital, Karachi Pakistan, from Jan to Aug 2019. Methodology: One hundred and sixty-eight women were included. 84 of 168 women had raised CRP, called as Exposed-Group, and 84 had normal CRP, called as Unexposed-Group. Blood samples were sent to assay serum CRP. Patients were then followed up until the third trimester to observe whether women with elevated serum CRP >5 mg/l or women with normal levels of CRP developed pre-eclampsia. Results: The average age of the women was 26.30±5.15 years. The pre-eclampsia was significantly high in the Exposed-Group as compared to the Unexposed-Group (p=0.019). The pre-eclampsia was two times more likely in the Exposed-Group as compared to the Unexposed-Group (RR=1.73; 95% CI 1.07-2.79). Conclusion: Pre-eclampsia is more likely to occur before 20 weeks of pregnancy in women having raised CRP. Therefore, effective monitoring of CRP could help in timely management and prevent severity.
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v74i1.8494