Green Synthesis of Pyrazol‑chromeno[2,3‑d]pyrimidinones Using SBA-Pr-SO3H as an Efficient Nanocatalyst

Hexagonal mesoporous silica (SBA-15) was prepared and then functionalized by(3-mercaptopropyl)trimethoxysilane. The obtained 3-mercaptopropyl functionalized SBA-15 (SBA-Pr-SH) was then oxidized using H2O2 in methanol under an acidic condition to give sulfonic acid functionalized mesoporous silica (S...

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Bibliographic Details
Published inIranian journal of chemistry & chemical engineering Vol. 36; no. 6; pp. 39 - 48
Main Authors Ghodsi Mohammadi Ziarani, Fatemeh Saidian, Parisa Gholamzadeh, Alireza Badiei, Ali Abolhasani Soorki
Format Journal Article
LanguageEnglish
Published Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 01.11.2017
Subjects
barbituric acid
green synthesis
multicomponent reactions
pyrazolone
salicylaldehyde
sba-pr-so3h
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Summary:Hexagonal mesoporous silica (SBA-15) was prepared and then functionalized by(3-mercaptopropyl)trimethoxysilane. The obtained 3-mercaptopropyl functionalized SBA-15 (SBA-Pr-SH) was then oxidized using H2O2 in methanol under an acidic condition to give sulfonic acid functionalized mesoporous silica (SBA-Pr-SO3H). The latter was characterized using different techniques (including TGA, BET, BJH, CHN, SEM, and TEM) and then used as a catalyst in organic synthesis. In the next step, SBA-Pr-SO3H catalyzed the three-component reaction of pyrazolone, salicylaldehydes, and barbituric acid in water under reflux condition. Through this procedure various pyrazolchromeno[2,3-d]pyrimidinone derivatives were obtained. The reaction conditions were completely green due to the use of water as a solvent and the presence of an environmentally benign catalyst.
ISSN:1021-9986
1021-9986