Molecular screening of lfs and pssm-i diseases in arabian horse population in turkey

Polysaccharide Storage Myopathy (PSSM) and Lavender Foal Syndrome (LFS) are inherited diseases in horse. PSSM-I, a point mutation in Glycogen Synthase-1 gen (GYS1) causes increased activation of the enzyme and abnormal polysaccharides formation. LFS caused by one nucleotide deletion in Myosin-Va (MY...

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Bibliographic Details
Published inVeteriner fakultesi dergisi Vol. 23; no. 2; pp. 339 - 342
Main Authors BİLGEN N, ÇINAR KUL B, ERTUĞRUL O, ERZURUM F
Format Journal Article
LanguageEnglish
Published Kafkas University, Faculty of Veterinary Medicine 01.03.2017
Subjects
arabian horses
lfs
pcr-rflp
pssm-i
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Summary:Polysaccharide Storage Myopathy (PSSM) and Lavender Foal Syndrome (LFS) are inherited diseases in horse. PSSM-I, a point mutation in Glycogen Synthase-1 gen (GYS1) causes increased activation of the enzyme and abnormal polysaccharides formation. LFS caused by one nucleotide deletion in Myosin-Va (MYO5A) leads frame shift mutation and premature termination of the protein. In the study, a total of 239 blood samples, taken from Anadolu (n=70), Karacabey (n=70) and Sultansuyu (n=99) stud farms were screened. Diseases related mutations were not detected in the sampled Arabian horse population.
ISSN:1309-2251
DOI:10.9775/kvfd.2016.16213