Advances of the Role of Lung Cancer Driver Gene and PD-1/PD-L1 Pathway Interaction in the Tumorigenesis and Progression of Non-small Cell Lung Cancer

• Published in: Zhongguo fei ai za zhi Vol. 20; no. 11; pp. 781 - 786
• Main Authors: Shi, Yan, Lv, Wang, Wang, Luming, Hu, Jian
• Format: Journal Article
• Language: Chinese
• Published: China Chinese Anti-Cancer Association Chinese Antituberculosis Association 20.11.2017; Chinese Anti-Cancer Association; Chinese Antituberculosis Association
• Subjects: Animals; B7-H1 Antigen - metabolism; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cytotoxicity; Epidermal growth factor; Gene Expression Regulation, Neoplastic; Genes; Humans; Ligands; Lung cancer; Lung neoplasms; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung tumor driver gene; Lymphocytes; Medical prognosis; Mutation; Programmed death 1; Programmed death 1 ligand; Thoracic surgery; China; Lung tumor driver gene; Programmed death 1; Programmed death 1 ligand; Lung neoplasms
• ISSN: 1009-3419; 1999-6187; 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2017.11.10

Programmed death 1 (PD-1) and programmed death 1 ligand (PD-L1) pathway is a key mechanism of immune regulation, and its abnormal activation in tumor tissues suggests that PD-1/PD-L1 pathway may participate in the regulation of tumor immune escape. Driver gene mutation which is known as a key factor in the tumorigenesis of non-small cell lung cancer (NSCLC), was also reported to play a important role in the process of tumor immune escape. It indicates that there is an interaction between driver gene and PD-1/PD-L1 pathway. The purpose of this paper is to review the relationship between PD-1/PD-L1 pathway and lung cancer driver gene, such as epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS) and echinoderm microtubuleassociated protein-like 4 - anaplastic lymphoma kinase (EML4-ALK) and to summarize the role of lung cancer driver gene and PD-1/PD-L1 pathway interaction in the tumorigenesis and progression of NSCLC.