The pigeonhole of occult hepatitis B

Occult hepatitis B (OHB), or persistent hepatitis B virus (HBV) viremia in surface-antigen-HBsAg-negative patients, has been recognized as a medical concern during the last decade. The exact magnitude, pathogenesis and clinical relevance of OHB are unclear. This review organizes the published data o...

Full description

Saved in:
Bibliographic Details
Published inActa medica Iranica Vol. 52; no. 8; pp. 582 - 590
Main Authors Dindoost, Payam, Chimeh, Narges, Hollinger, Blain F, Saberfar, Esmaeil, Norouzi, Mehdi, Jazayeri, Seyed Mohammad
Format Journal Article
LanguageEnglish
Published Iran Tehran University of Medical Sciences 2014
Subjects
Animals
HBsAg mutations
HBV diagnosis
Hepatitis B
Hepatitis B - blood
Hepatitis B - diagnosis
Hepatitis B - virology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - isolation & purification
Humans
Occult Hepatitis B infection
Online AccessGet full text

Cover

More Information
Summary:Occult hepatitis B (OHB), or persistent hepatitis B virus (HBV) viremia in surface-antigen-HBsAg-negative patients, has been recognized as a medical concern during the last decade. The exact magnitude, pathogenesis and clinical relevance of OHB are unclear. This review organizes the published data on OHB and presents an overview of the current hypotheses on OHB's pathogenesis and clinical relevance.Many explanations have been offered for the pathogenesis of OHB, ranging from the inability of standard immunoassays to diagnose OHB to the involvement of the versatile virus-host factors. Also, special care should be taken regarding the diagnosis of OBH. It seems that both shared viral-host factors are involved in the pathogenesis of OBH. Further molecular studies on cohort patients group need to explore such association.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0044-6025
1735-9694