Perioperative Outcomes and Long-term Survival in Clinically Early-stage Thymic 
Malignancies: Video-assisted Thoracoscopic Thymectomy versus Open Approaches

• Published in: Zhongguo fei ai za zhi Vol. 19; no. 7; pp. 453 - 458
• Main Authors: Wang, Hao, Gu, Zhitao, Ding, Jianyong, Tan, Lijie, Fu, Jianhua, Shen, Yi, Wei, Yucheng, Zhang, Peng, Han, Yongtao, Chen, Chun, Zhang, Renquan, Li, Yin, Chen, Ke-Neng, Chen, Hezhong, Liu, Yongyu, Cui, Youbing, Wang, Yun, Pang, Liewen, Yu, Zhentao, Zhou, Xinming, Liu, Yangchun, Liu, Yuan, Fang, Wentao
• Format: Journal Article
• Language: Chinese
• Published: China Chinese Anti-Cancer Association Chinese Antituberculosis Association 20.07.2016; Chinese Anti-Cancer Association; Chinese Antituberculosis Association
• Subjects: Adult; Aged; Cancer therapies; China; Cohort Studies; Disease-Free Survival; Esophageal cancer; Female; Hospitals; Humans; Male; Medical prognosis; Middle Aged; Neoplasm Staging; Open surgery; Perioperative Period; Retrospective Studies; Surgeons; Surgery; Surgical techniques; Thoracic surgery; Thoracic Surgery, Video-Assisted; Thymectomy; Thymic malignancies; Thymoma - mortality; Thymoma - pathology; Thymoma - surgery; Thymus Neoplasms - mortality; Thymus Neoplasms - pathology; Thymus Neoplasms - surgery; Tumors; Video-assisted Thoracoscopic Surgery (VATS); Beijing China; China; Japan
• ISSN: 1009-3419; 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2016.07.07

Video-assisted thoracoscopic surgery (VATS) theoretically offers advantages over open thymectomy for clinically early-stage (Masaoka-Koga stage I and II) thymic malignancies. However, longterm outcomes have not been well studied. We compared the postoperative outcomes and survival from a cohort study based on the database of the Chinese Alliance for Research in Thymomas (ChART). Between 1994 and 2012, data of 1,117 patients having surgery for clinically early-stage (Masaoka-Koga stage I and II) tumors were enrolled for the study. Among them, 241 cases underwent VATS thymectomy (VATS group), while 876 cases underwent open thymectomy (Open group). Univariate analyses were used to compare the clinical character and perioperative outcomes between the two groups. And multivariate analysis was performed to determine the independent predictive factors for long-term survival. Compared with the Open group, the VATS group had higher percentage of total thymectomy (80.5% vs 73.9%, P=0.028), resection rate (98.8% vs 88.7