Evaluation of plasma concentrations of homocysteine, IL-6, TNF-alpha, hs-CRP, and total antioxidant capacity in patients with end-stage renal failure

• Published in: Acta medica Iranica Vol. 52; no. 12; pp. 893 - 898
• Main Authors: Babaei, Mahin, Dashti, Nasrin, Lamei, Navid, Abdi, Khosrou, Nazari, Farhad, Abbasian, Sepideh, Gerayeshnejad, Siavash
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 2014
• Subjects: Adult; Antioxidants - metabolism; Biomarkers - blood; C-Reactive Protein - metabolism; Cardiovascular disease; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; End stage renal disease; Female; Hemodialysis; homocysteine; Homocysteine - blood; Humans; Hyperhomocysteinemia - epidemiology; Inflammation - blood; Interleukin-6 - blood; Interleukins; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - therapy; Male; Middle Aged; Oxidative Stress; Renal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha - blood
• ISSN: 0044-6025; 1735-9694

It has been proved that hyperhomocysteinemia has a high prevalence in patients with end-stage renal disease (ESRD), which may contribute to the high cardiovascular risk in these patients. Cardiovascular disease is the first cause of high mortality rate in ESRD patients. The aim of the present study was to assess five important factors in patients with ESRD (the amount of homocysteine, IL-6, TNF-alpha, hs-CRP, and Total Antioxidant Capacity). These factors were surveyed in ESRD patients to compare with healthy subjects. In a cross-sectional study, we enrolled 80 patients on maintenance hemodialysis and measured the inflammatory and oxidative stress indicators. The plasma samples were assayed for five above mentioned variables using standard protocols. Two-hour post hemodialysis plasma samples were also assayed for TAC. Plasma levels of inflammation markers, IL-6 and hs-CRP, homocysteine were significantly increased in ESRD group versus control group. This increase was also found in TNF-α levels as compared to the controls, but the differences were not statistically significant. Also, the post dialysis samples had significantly lower levels of TAC as compared to predialysis ones.