Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii

• Published in: Pharmaceutical Sciences Vol. 26; no. 2; pp. 184 - 192
• Main Authors: Mardaneh, Jalai, Beyzaei, Hamid, Hashemi, Seyed Hadi, Ghasemi, Behzad, Rahdar, Abbas
• Format: Journal Article
• Language: English
• Published: Tabriz Tabriz University of Medical Sciences 01.06.2020
• Subjects: acinetobacter baumannii; antibacterial effect; Antibiotics; Antimicrobial agents; Antioxidants; Cancer; Copper; cu/fe3o4@sio2 nanocomposites; curcuma longa; Drug resistance; E coli; Ethanol; green tea catechins; Metabolism; Nanocomposites; Nanoparticles; Natural products; Nosocomial infections; Pathogens; Staphylococcus infections; Tea; trachyspermum ammi; India
• ISSN: 1735-403X; 2383-2886
• DOI: 10.34172/PS.2020.12

Some thiazole derivatives were used to treat cancer, AIDS, blood lipids and hypertension diseases.19 Some synthesized thiazoles showed anti-inflammatory and antioxidant activities as well as blocking properties on anopheles mosquitoes or trypanosomes and fungi Candida albicans.20 Antimicrobial effects of thiazole derivatives were evaluated against a broad spectrum of bacterial pathogens such as Pseudomonas aeruginosa, Staphylococcus epidermidis and Bacillus subtilis.21 Imidazolidine ring is present in midazolam, phenytoin and ketoconazole that applied as anesthetic, anti-seizure and antifungal medicines.22-31 In addition, antibacterial effect of synthetic imidazolidines were assessed on S. aureus, Pseudomonas aeruginosa and E. coli.32,33 Antifungal, antimalarial, anticancer and anti-inflammatory activities were observed with compounds containing tetrahydropyrimidine core.34-38 Tetrahydropyrimidine derivatives could efficiently confront Pseudomonas aeruginosa and Klebsiella pneumoniae.39 To expand and discover new antimicrobial agents, inhibitory potentials of synthetic thiazole, imidazole and tetrahydropyrimidine derivatives, Cu/Fe3O4@ SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extract of Trachyspermum ammi, Curcuma longa and green tea catechins were studied against nonresistant and antibiotic-resistant strains of A. baumannii. Extract was dissolved in 10% DMSO at initial concentrations of 10240 pg ml-1, and sterilized by 0.22 pm syringe filter.40 Preparation of Cu/Fe3O@SiO2 nanocomposites The Fe3O4 nanoparticles were prepared using electrochemical system as previously reported.41 A solution containing 0.90 g of copper chloride in 50 ml of aqueous ethanol 50% was added to a stirred mixture in an electrochemical cell including 0.27 g of Fe3O4@SiO2 in 50 ml of aqueous ethanol 50%. [...]the particles were separated using a magnet, washed with distillated water and calcined at 180 °C for 13 h to give Cu/Fe3O4@SiO2 nanocomposites.41 Synthesis of thiazoles 3a-f A mixture including 1 mmol of thioamide 1 (0.23 g,), 1-bromocarbonyl compounds 2a-f and sodium bicarbonate (0.08 g) in 1 ml DMF was stirred at ambient temperature (Figure 1). [...]the 0.5 McFarland turbidity standard of each bacterial strain was prepared in Mueller-Hinton broth (MHB) medium.44 Inhibition zone diameter (IZD) measurement 100 pl of bacterial suspension was spread on a plate 10 cm containing Mueller-Hinton agar (MHA).