Specific features of hypolipidemic therapy in patients with abdominal ischemic disease

• Published in: Terapevtic̆eskii arhiv Vol. 84; no. 8; pp. 18 - 21
• Main Author: Oĭnotkinova, O Sh
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 01.01.2012
• Subjects: abdominal ischemic disease; Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents - administration & dosage; Anticholesteremic Agents - adverse effects; Aorta, Abdominal - drug effects; Aorta, Abdominal - pathology; Atherosclerosis - complications; Atherosclerosis - drug therapy; Atorvastatin Calcium; Cholagogues and Choleretics - administration & dosage; Cholagogues and Choleretics - adverse effects; Drug Therapy, Combination; Fatty Liver - drug therapy; Female; Heptanoic Acids - administration & dosage; Heptanoic Acids - adverse effects; Humans; hypolipidemic therapy; Ischemia - complications; Ischemia - drug therapy; ischemic hepatopathy; Male; Middle Aged; Pyrroles - administration & dosage; Pyrroles - adverse effects; statins; ursodeoxycholic acid; Ursodeoxycholic Acid - administration & dosage; Ursodeoxycholic Acid - adverse effects; Young Adult
• ISSN: 0040-3660; 2309-5342

To evaluate the efficiency and safety of combined drug therapy incorporating Ursofalk (Dr Falk Pharma GmbH, Germany) and a low-dose statin on the clinical course of the disease and blood lipid composition parameters in high-risk patients with abdominal ischemic disease (AID) and hepatic ischemic steatosis resulting from atherosclerotic lesion of the abdominal aorta (AA) and its unpaired visceral branches (UVB). One hundred and thirty-nine patients (95 (68.3%) men and 44 (31.7%) women, aged 18-87 years) with AID and ischemic hepatopathy were examined and treated. AID in the examinees was verified by color duplex scanning and computed tomographic angiography of AA UVB, as well as by X-ray contrast aortography. The patients were treated with Ursofalk 10-15 mg/kg/day in combination with atorvastatin 10-20 mg/day. Due to the combination therapy, abdominal pains became less significant in the majority of patients and disappeared in some subjects. The same positive changes were also observed in the signs of intestinal dysfunction. There was an improvement in blood lipid composition parameters. No substantial weight changes were noted in the patients during the treatment. No adverse reactions occurred due to the combined use of Ursofalk and atorvastatin. It is reasonable to co-administer urosofalk and statins as an agent of hypolipidemic therapy in patients with AID concurrent with disseminated atherosclerosis and dyslipidemia that is accompanied by fatty infiltration of the liver with elements of fibrosis in 90% of cases and that is a pre-stage of steatohepatitis.