Fructose-Based Metal–Organic Framework as a Means to Synthesize Sr-Loaded Chitosan Nanospheres with NLO Properties for Theranostic Applications in Radiotherapy

Chitosan is a biodegradable polymer derived from chitin, which is a versatile material for various biological applications due to its attractive properties such as biocompatibility, biodegradability, and non-toxicity. Furthermore, chitosan possesses Second Harmonic Generation (SHG) properties that a...

Full description

Saved in:
Bibliographic Details
Published inInorganics Vol. 12; no. 9; p. 231
Main Authors Cioci, Alma, Benzi, Paola, Canepa, Carlo, Mortati, Leonardo, Alvarez de la Paz, Antonio, Garnica-Palafox, Itzel Marisol, Sánchez-Arévalo, Francisco Manuel, Dante, Roberto C, Marabello, Domenica
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2024
Subjects
Biocompatibility
Biodegradability
Biological properties
Biosensors
Cancer therapies
Cellulose
Chemical synthesis
Chitin
Chitosan
chitosan nanospheres
Fourier transforms
Fructose
Hydrogels
Metal industry
Metal-organic frameworks
Microscopy
Nanospheres
Pharmaceuticals
Polymers
Radiation therapy
Radiochemistry
Radioisotopes
radiopharmaceutical
Radiotherapy
Second harmonic generation
second harmonic generation properties
Spectrum analysis
Strontium
Strontium 89
theranostics
Toxicity
Online AccessGet full text

Cover

More Information
Summary:Chitosan is a biodegradable polymer derived from chitin, which is a versatile material for various biological applications due to its attractive properties such as biocompatibility, biodegradability, and non-toxicity. Furthermore, chitosan possesses Second Harmonic Generation (SHG) properties that are useful for biosensing applications. In this work, we explored the possibility of exploiting chitosan-based nanospheres as SHG-based biosensors, and also as carriers of [sup.89]Sr radionuclide, an Active Pharmaceutical Ingredient (API) for radiopharmaceutical treatments in cancer therapy. To opportunely load the Sr ion on the nanospheres, we used a fructose-based Metal–Organic Framework, with the formula [Sr(C[sub.6]H[sub.12]O[sub.6])[sub.2](H[sub.2]O)[sub.2]]Cl[sub.2]·H[sub.2]O, because the sugar was able to drive the Sr ions on the chitosan matrix. Sr-loaded chitosan nanospheres were synthesized, characterized, and their SHG response was measured. The results encouraged us to propose the nanospheres for theranostic purposes, i.e., valuable for both therapeutic and diagnostic applications at the same time.
ISSN:2304-6740
2304-6740
DOI:10.3390/inorganics12090231