Introducing the Tehran Heart Center's Premature Coronary Atherosclerosis Cohort: THC-PAC Study

• Published in: Journal of Tehran University Heart Center Vol. 10; no. 1; p. 34
• Main Authors: Abbasi, Seyed Hesameddin, Kassaian, Seyed Ebrahim, Sadeghian, Saeed, Karimi, Abbasali, Saadat, Soheil, Peyvandi, Flora, Jalali, Arash, Davarpasand, Tahereh, Shahmansouri, Nazila, Lotfi-Tokaldany, Masoumeh, Abchouyeh, Maryam Amiri, Isfahani, Farah Ayatollahzade, Rosendaal, Frits
• Format: Journal Article
• Language: English
• Published: Tehran Tehran University of Medical Sciences 2015
• Subjects: Cardiology; Epidemiologic studies • Cohort studies • Coronary artery disease • Young adult; Health risk assessment; Heart attacks; Mortality; Studies
• ISSN: 1735-8620; 2008-2371

Data on premature coronary artery disease (CAD) are scarce. The Tehran Heart Center's Premature Coronary Atherosclerosis Cohort Study is the first study of its kind in the Middle East to assess major adverse cardiac events (MACE) in young CAD patients. The cohort consists of CAD patients, males ≤ 45 years old and females ≤ 55 years old. A 10-year follow-up, via either clinical visits or telephone calls at least once a year, was commenced in August 2012. The end point is considered MACE, encompassing death, myocardial infarction, stroke, new coronary involvement, percutaneous coronary intervention, and coronary artery bypass grafting. The cohort comprises 1,232 eligible patients at a mean age of 45.1 years. High frequencies of conventional risk factors, including hyperlipidemia, hypertension, positive family history, cigarette smoking, and diabetes mellitus, were seen in the participants. The mean body mass index (BMI) of the enrolled patients was high, and 532 and 440 of them were overweight and obese, respectively.