Research Progress on Exosome in Malignant Tumors

• Published in: Zhongguo fei ai za zhi Vol. 23; no. 8; pp. 689 - 694
• Main Authors: ZHENG, Yujun, JIANG, Wei, CHEN, Dongyan, WANG, Lei, LI, Yanjun, DAI, Lulu, HUANG, Lei, WANG, Mingji
• Format: Journal Article
• Language: Chinese
• Published: Tianjin Chinese Anti-Cancer Association Chinese Antituberculosis Association 01.08.2020; Chinese Anti-Cancer Association; Chinese Antituberculosis Association
• Subjects: Angiogenesis; Apoptosis; Biomarkers; Bone marrow; Dendritic cells; exosomes; Fibroblasts; Gene expression; Growth factors; Ligands; Liver cancer; Lung cancer; malignant tumor; Metastasis; MicroRNAs; Ovarian cancer; Prostate; Tumor necrosis factor-TNF; tumorigenesis
• ISSN: 1009-3419; 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2020.101.28

“体液活检”是近些年恶性肿瘤研究的热点，肿瘤细胞外泌体因携带其“母体”肿瘤细胞的部分功能性蛋白及基因，介导信息传递、参与调控机体的生理功能及病理状态在肿瘤的发生发展过程中起着重要作用，并作为肿瘤液态活检的一种新途径。本文旨在对外泌体的结构、生物特性和检测方法在恶性肿瘤发生发展及临床诊断治疗中的作用进行综述。 “Liquid biopsy” have been intensively studied in recent decades. The exosomes carry their maternal partial functional proteins and genes. As a form of intercellular vesicular transport, exosome-mediated intercellular communication participates in a variety of physiological and pathological processes. The information transmission mediated by exosomes is associated with pathophysiological status and plays an important role in the pathogenesis of cancer. Their detection may be beneficial for the diagnosis and treatment of tumor. This article reviews advances in knowledge on the exosome properties, the effect of exosomes on malignant tumorigenesis, and their clinical application. The data will provide a reference for clinical practitioners.