The Golgi Apparatus: Panel Point of Cytosolic Ca2+ Regulation

The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca 2+ store because different Ca 2+ regulators, such as the inositol-1,4,5-tr...

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Bibliographic Details
Published inNeuro-Signals Vol. 21; no. 3-4; pp. 272 - 284
Main Authors Li, Li-Hua, Tian, Xiang-Rong, Jiang, Zheng, Zeng, Liu-Wang, He, Wen-Fang, Hu, Zhi-Ping
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Cell Physiol Biochem Press GmbH & Co KG 22.06.2013
Subjects
Ca2+ regulators
Cytosolic calcium
Golgi apparatus
Intracellular calcium store
Review
Ca2+ regulators
Cytosolic calcium
Intracellular calcium store
Golgi apparatus
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Summary:The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca 2+ store because different Ca 2+ regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca 2+ -ATPase and secretory pathway Ca 2+ -ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca 2+ release and uptake in the GA have now been established. Here, based on careful backward looking on compartments and patterns in GA Ca 2+ regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca 2+ adjustment model, in which GA acts as part of the panel point.
ISSN:1424-862X
1424-8638
DOI:10.1159/000350471