Phytochemical analysis and pharmacological activities of essential oils extracted from Zingiber officinale (Roscoe) used in mediterranean diet: in vitro and in silico studies

For their pungency and tanginess, ginger rhizomes (Zingiber officinale) are often used in cooking. Ginger has long been used in traditional medicine and home remedies to treat pain and inflammation. This research tests Z. officinale (EOZ) essential oils' chemical composition, insecticidal, and...

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Published inInternational journal of food properties Vol. 27; no. 1; pp. 1180 - 1199
Main Authors Aimad, Allali, Mssillou, Ibrahim, Siddique, Farhan, Mohmmed, Bouslamti, Abdelkrim, Agour, Kara, Mohammed, Salamatullah, Ahmad Mohammad, El Moussaoui, Abdelfattah, Bourhia, Mohammed, Dauelbait, Musaab, Khallouki, Farid, Mohamed, Fadli
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 31.12.2024
Subjects
antioxidant activity
bruchid
Callosobruchus maculatus
chickpea weevil
essential oils
Ginger
GC-MS
insecticidal potential
in vitro studies
chickpea weevil
Ginger
essential oils
Callosobruchus maculatus
antioxidant activity
docking experiment
bruchid
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Summary:For their pungency and tanginess, ginger rhizomes (Zingiber officinale) are often used in cooking. Ginger has long been used in traditional medicine and home remedies to treat pain and inflammation. This research tests Z. officinale (EOZ) essential oils' chemical composition, insecticidal, and antioxidant properties in vitro and in silico. EOZ yielded 0.69% of root mass with 23 chemicals. The main chemicals in EOZ were alpha-zingiberene (23.850%), Geranial (14.160%), and (E,E)-alpha-farnesene (9.980%). EOZ demonstrated noteworthy antioxidant activity in all tests, with an IC50 of 9.53 +/- 0.41 mg/mL in the DPPH test and an EC50 of 87.46 +/- 3.19 mg/mL in the FRAP system. The results indicate that EOZ has strong efficacy against C. maculatus, even at low concentrations (1.00 mu L/100 g). Note that EOZ killed 20 +/- 0% and 13.33 +/- 4.44% of adult C. maculatus in inhalation and contact tests, respectively. High concentration (20.00 mu L/100 g) resulted in 100% adult mortality in inhalation tests and 96.67 +/- 4.44% mortality in contact testing. We then used molecular docking to identify EO major component binding modes by targeting insecticidal and antioxidant protein structures 1R20 and 1R4U. This research helps create insecticides and antioxidants from common ginger essential oil.
ISSN:1532-2386
1094-2912
1532-2386
DOI:10.1080/10942912.2024.2387937