Lack of Lloviu Virus Disease Development in Ferret Model

• Published in: Emerging infectious diseases Vol. 30; no. 12; pp. 2639 - 2642
• Main Authors: Fletcher, Paige, O'Donnell, Kyle L, Rhoderick, Joseph F, Henderson, Corey W, Okumura, Atsushi, Bushmaker, Trenton, Takada, Ayato, Clancy, Chad S, Kemenesi, Gábor, Marzi, Andrea
• Format: Journal Article
• Language: English
• Published: United States Centers for Disease Control and Prevention 01.12.2024
• Subjects: Animals; Disease Models, Animal; Dispatch; Ferrets; Filoviridae; Filoviridae Infections - virology; Humans; Lack of Lloviu Virus Disease Development in Ferret Model

The first isolate of the emerging filovirus Lloviu virus (LLOV) was obtained in 2022. No animal disease models have been established. We assessed the pathogenic potential of LLOV in ferrets after intranasal, intramuscular, or aerosol exposure. The lack of disease development shows ferrets are not a...