Lack of Lloviu Virus Disease Development in Ferret Model

The first isolate of the emerging filovirus Lloviu virus (LLOV) was obtained in 2022. No animal disease models have been established. We assessed the pathogenic potential of LLOV in ferrets after intranasal, intramuscular, or aerosol exposure. The lack of disease development shows ferrets are not a...

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Published inEmerging infectious diseases Vol. 30; no. 12; pp. 2639 - 2642
Main Authors Fletcher, Paige, O'Donnell, Kyle L, Rhoderick, Joseph F, Henderson, Corey W, Okumura, Atsushi, Bushmaker, Trenton, Takada, Ayato, Clancy, Chad S, Kemenesi, Gábor, Marzi, Andrea
Format Journal Article
LanguageEnglish
Published United States Centers for Disease Control and Prevention 01.12.2024
Subjects
Animals
Disease Models, Animal
Dispatch
Ferrets
Filoviridae
Filoviridae Infections - virology
Humans
Lack of Lloviu Virus Disease Development in Ferret Model
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Summary:The first isolate of the emerging filovirus Lloviu virus (LLOV) was obtained in 2022. No animal disease models have been established. We assessed the pathogenic potential of LLOV in ferrets after intranasal, intramuscular, or aerosol exposure. The lack of disease development shows ferrets are not a disease model for LLOV.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1080-6059
1080-6040
1080-6059
DOI:10.3201/eid3012.240818