Effects of hyperbaric pressure on the oxidative stress status in healthy subjects

ABSTRACT Introduction: In the hyperbaric pressure environment the partial pressure of each gas component increases, which increases oxygen partial pressure. This causes the generation of free radicals and oxidative stress. Objective: To determine the effects of hyperbaric pressure on the oxidative s...

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Bibliographic Details
Published inRevista cubana de medicina militar Vol. 52; no. 2; p. e02302506
Main Authors Huu Nguyen, Ben, Van Phan, Manh, Duy Bui, Hoan, Minh Nguyen, Phuong
Format Journal Article
LanguagePortuguese
Spanish
Published Centro Nacional de Información de Ciencias Médicas; Editorial Ciencias Médicas 01.04.2023
ECIMED
Subjects
biomarkers
catalase
decompression
free radicals
healthy volunteers
malondialdehyde
MEDICINE, LEGAL
MEDICINE, RESEARCH & EXPERIMENTAL
oxidative stress
superoxide dismutase
free radicals
catalasa
healthy volunteers
estrés oxidativo
biomarcadores
radicales libres
voluntarios saludables
biological biomarker
superoxide dismutase
decompression
superóxido dismutasa
malondialdehyde
malondialdehído
catalase
oxidative stress
descompresión
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Summary:ABSTRACT Introduction: In the hyperbaric pressure environment the partial pressure of each gas component increases, which increases oxygen partial pressure. This causes the generation of free radicals and oxidative stress. Objective: To determine the effects of hyperbaric pressure on the oxidative stress status in healthy subjects. Methods: 29 healthy men performed standardized hyperbaric chamber dive to a depth of 30 meters of water (msw) for 30 minutes. Blood samples were collected before compression, immediately after decompression and 1 hour after decompression. The levels of Malondialdehyde, Catalase and Superoxide Dismutase were measured in blood samples. Results: Malondialdehyde activity increased immediately after decompression and recovered at 1 hour after decompression. Superoxide Dismutase enzyme activity decreased immediately after decompression as well as 1 hour after decompression. Catalase enzyme activity increased immediately after decompression, which was significant at 1 hour after decompression. Conclusion: Changes in the biological markers Malondialdehyde, Catalase and Superoxide Dismutase suggest the appearance of oxidative stress under the influence of a hyperbaric pressure environment.
ISSN:1561-3046
1561-3046