The point about oxidative stress in molluscs

In the normal metabolism of the aerobic cell, oxygen is used for various biochemical reactions. Because of its two lone electrons of parallel spins, the molecular oxygen is stable. However, oxygen generates Reactive Oxygenated Species or ROS by successive transfer of electrons. The ROS have a strong...

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Bibliographic Details
Published inInvertebrate survival journal Vol. 2; no. 2; pp. 91 - 104
Main Authors Manduzio, Hélène, Rocher, Béatrice, Durand, F., Galap, C, Leboulenger, F
Format Journal Article
LanguageEnglish
Published ISJ 2005
University of Modena and Reggio Emilia
Subjects
antioxidant
Environmental Sciences
molluscs
oxidative stress
ROS
xenobiotics
molluscs
antioxidant
xenobiotics
oxidative stress
ROS
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Summary:In the normal metabolism of the aerobic cell, oxygen is used for various biochemical reactions. Because of its two lone electrons of parallel spins, the molecular oxygen is stable. However, oxygen generates Reactive Oxygenated Species or ROS by successive transfer of electrons. The ROS have a strong reactivity and can potentially interact with all other cellular components (lipids, proteins, DNA). They are at the origin of oxidations in chain by creating radicals. The cell has antioxidant systems which limit the effects of the ROS. These systems are composed of enzymes such as glutathione reductase, glutathione peroxidase, etc., and molecules of nonenzymatic nature like the reduced glutathione or vitamins. The production and the destruction of the radicals of oxygen coexist in a weak balance. If this balance is broken in favour of the ROS, an oxidative stress is generated. Xenobiotics could influence this balance by catalysing production of ROS.
ISSN:1824-307X
1824-307X