Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells

Objective To explore the expression characteristics of BAIAP2L1 in cervical cancer（CC） and its regulatory role in tumor cell metastasis. Methods The correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological c...

Full description

Saved in:
Bibliographic Details
Published inZhongliu fangzhi yanjiu Vol. 52; no. 6; pp. 481 - 490
Main Authors Zhao, Jueying, Han, Zhuoying, Feng, Lulu, Wang, Chenlong, Zhang, Li, Luo, Chao, Wang, Qilong
Format Journal Article
LanguageChinese
English
Published Tianjin China Anti-Cancer Association 2025
Magazine House of Cancer Research on Prevention and Treatment
Subjects
baiap2l1
Cancer
Cell growth
Cell migration
Cell proliferation
Cervical cancer
Correlation analysis
Gene set enrichment analysis
Gene silencing
Medical prognosis
Metastases
Metastasis
Phenotypes
Prognosis
Risk factors
Tumors
Online AccessGet full text

Cover

More Information
Summary:Objective To explore the expression characteristics of BAIAP2L1 in cervical cancer（CC） and its regulatory role in tumor cell metastasis. Methods The correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological correlation analyses were conducted by employing R language. The effect of BAIAP2L1 knockdown on CC cell proliferation, invasion, migration, and epithelial-mesenchymal transition（EMT） were further investigated through gene silencing approaches. Results BAIAP2L1 expression was significantly upregulated in CC tissues（Padj ＜0.001） and it was identified as an independent risk factor for patient mortality（HR=2.808,P=0.03）. Elevated BAIAP2L1 levels showed significant correlations with poor overall survival, advanced T/N stage, recurrence, and metastasis（all P＜0.05）. Functional enrichment analysis revealed its involvement in tumor metastasis-related pathways. The knockdown of BAIAP2L1 significantly attenuated CC cell proliferation, invasion, and migration and suppressed key EMT processes（all P＜0.05）. Conclusion BAIAP2L1is overexpressed in CC tissues and associated with patient prognosis and metastasis. The targeted inhibition of BAIAP2L1 can effectively curb tumor progression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1000-8578
DOI:10.3971/j.issn.1000-8578.2025.24.0951