Setup Error and Its Influencing Factors in Radiotherapy for Spinal Metastasis

• Published in: Zhongliu fangzhi yanjiu Vol. 52; no. 5; pp. 400 - 404
• Main Authors: Qin, Wenhua, Feng, Xin, Wang, Zengzhou, Chu, Shangnan, Wang, Hong, Wu, Shiyu, Chen, Cheng, Huan, Fukui, Liang, Bin, Zhang, Tao
• Format: Journal Article
• Language: Chinese; English
• Published: Tianjin China Anti-Cancer Association 2025; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: bmi; Computed tomography; cone beam ct; influencing factors; Linear accelerators; Medical imaging; Metastases; Metastasis; Radiation therapy; radiotherapy; setup error; spinal bone metastasis; Spine; Spine (cervical); Spine (lumbar); Spine (thoracic); Statistical analysis
• ISSN: 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2025.24.1084

Objective To investigate the setup error in patients with spinal bone metastasis who underwent radiotherapy under the guidance of kilovoltage cone-beam CT (KV-CBCT). Methods A total of 118 patients with spinal metastasis who underwent radiotherapy, including 17 cases of cervical spine, 62 cases of thoracic spine, and 39 cases of lumbar spine, were collected. KV-CBCT scans were performed using the linear accelerators from Elekta and Varian's EDGE system. CBCT images were registered with reference CT images in the bone window mode. A total of 973 data were collected, and 3D linear errors were recorded. Results The patients with spinal bone metastasis were grouped by site, height, weight, and BMI. The P value of the patients grouped only by site was P<0.05, which was statistically significant. Conclusion When grouped by site in the 3D direction, the positioning effect of cervical spine is better than that of thoracic and lumbar spine. The positioning effect of the thoracic spine is better in the head and foot direction but worse in the left and right direction compared with that of the lumbar spine. Instead of extending or narrowing the margin according to the BMI of patients with spinal metastasis, the margin must be changed according to the site of spinal bone metastasis.