Expression of GPNMB, ERK, MMP3 and MMP9 in Primary Lesion and Bone Metastasis of Renal Cell Carcinoma and Their Correlation

• Published in: Zhongliu fangzhi yanjiu Vol. 47; no. 5; pp. 367 - 371
• Main Authors: Zhai, Jianpo, Liu, Ning, Wang, Hai, Wang, Haidong, Man, Libo
• Format: Journal Article
• Language: Chinese
• Published: Tianjin China Anti-Cancer Association 01.05.2020; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: Appendicular skeleton; Axial skeleton; bone metastasis; Correlation analysis; erk; Extracellular signal-regulated kinase; Gelatinase B; gpnmb; Immunohistochemistry; Kidney cancer; Lesions; Metastases; Metastasis; mmp3; mmp9; Renal cell carcinoma; Tumors
• ISSN: 1000-8578; 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2020.19.1273

Objective To investigate the expression and significance of GPNMB, ERK, MMP3 and MMP9 in primary lesion and bone metastasis of renal cell carcinoma, and to analyze their correlation. Methods The expression of GPNMB, ERK, MMP3 and MMP9 in primary lesion and bone metastases of renal cell carcinoma were detected by immunohistochemistry. The correlation of GPNMB expression with the clinical pathological features of renal cell carcinoma patients with bone metastasis was analyzed. Results GPNMB expression in primary tumor and bone metastasis were 3.65±1.87 and 5.91±3.68. There were 4, 1 and 3 cases of axial, appendicular and both axial and appendicular bone metastasis in the high GPNMB expression group, while there were 10, 5 and 0 cases in low expression group, respectively(P=0.035). The expression of ERK, MMP3 and MMP9 between the high and low GPNMB expression groups in primary tumor were 7.25±2.55 vs. 2.47±0.64, 5.25±1.91 vs. 2.33±0.49 and 7.00±2.98 vs. 2.27±0.46; while they were 7.45±3.67 vs. 3.75±1.66, 6.45±2.