Treatment and Outcome of Merkel Cell Carcinoma in A Single Center

• Published in: Zhongliu fangzhi yanjiu Vol. 50; no. 4; pp. 364 - 369
• Main Authors: Ren, Mengwei, Xue, Xuemin, Liu, Peng
• Format: Journal Article
• Language: Chinese
• Published: Tianjin China Anti-Cancer Association 01.04.2023; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: Cancer; Chemotherapy; cutaneous neuroendocrine carcinoma; Fatalities; Health services; Immune checkpoint inhibitors; Immunotherapy; Laboratory tests; merkel cell carcinoma; Metastases; Patients; PD-1 protein; PD-L1 protein; Radiation therapy; radiotherapy; Skin cancer; Surgery
• ISSN: 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2023.22.1101

Objective To investigate the clinical features, treatment, and outcome characteristics of patients with Merkel cell carcinoma. Methods The clinical manifestations, laboratory tests, diagnosis and treatment, and follow-up data of six patients with Merkel cell carcinoma were retrospectively analyzed. Results Among the six patients with Merkel cell carcinoma, four were males and two were females, with a median age of 66 years old (57-76 years old). All six patients presented with skin swelling, and the clinical stages were as follows: stageⅠ in three patients, stage Ⅲ in one patient, and stage IV in two patients. Two patients were treated with surgery alone, three patients with surgery combined with radiotherapy and/or chemotherapy, and one patient with immunotherapy combined with chemotherapy. Until the follow-up time, four patients had no disease progression, one patient died because of disease progression, and one patient remained under treatment. Conclusion Limited-stage Merkel cell carcinoma is primarily tr