A Multi-center Randomized Controlled Clinical Study of Kang'ai Injection Combined with OFL Regimen on Gastric Cancer Patients

• Published in: Zhongliu fangzhi yanjiu Vol. 46; no. 3; pp. 257 - 261
• Main Authors: Sun, Xin, Li, Ping, Liang, Hui, Zhou, Jinhua, Zha, Mingbao, Liu, Zhenchang
• Format: Journal Article
• Language: Chinese
• Published: Tianjin China Anti-Cancer Association 01.03.2019; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: 5-Fluorouracil; Cancer; Chemotherapy; clinical study; Control methods; Effectiveness; Gastric cancer; Injection; kang'ai injection; Neurotoxicity; ofl regimen; Oxaliplatin; Patients; Quality of life; random; Randomization; Side effects; Thrombocytopenia
• ISSN: 1000-8578; 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2019.18.1177

Objective To investigate the clinical efficacy and safety of Kang'ai injection combined with Oxaliplatin, Fluorouracil and Leucovorin (OFL regimen) in the treatment of patient with gastric cancer. Methods A multi-center randomized controlled study was conducted on 300 patients with gastric cancer treated in five hospitals from March 2012 to June 2015. The patients were randomly divided into control group and experimental group. The control group were treated with OFL regimen. The experimental group were treated with Kang'ai injection on the basis of the treatment of control group. The short- and long-term clinical efficacy after treatment and adverse reactions during the treatment were observed and compared between the two groups. Results (1) The short-term clinical efficacy of the experimental group was significantly higher than that in the control group (35.62% vs. 22.86%, P<0.05); (2) The quality of life of patients in the experimental group after the treatment was significantly better than that in the con