1H‐31P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis

Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and...

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Published inAnnals of clinical and translational neurology Vol. 6; no. 7; pp. 1332 - 1337
Main Authors Guillevin, Carole, Agius, Pierre, Naudin, Mathieu, Herpe, Guillaume, Ragot, Stéphanie, Maubeuge, Nicolas, Philippe Neau, Jean, Guillevin, Rémy
Format Journal Article
LanguageEnglish
Published Hoboken John Wiley and Sons Inc 01.07.2019
Wiley
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Summary:Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.
Bibliography:Funding information
None declared.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.50825