Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida

This study aimed to analyze the phytochemical profile of essential oil obtained from the leaves of Coriandrum sativum L., and its antifungal activity against Candida spp. The research consisted of an in vitro study including collecting the vegetable product, analysis of its macronutrients, extractio...

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Published inBrazilian journal of biology Vol. 83; p. e264875
Main Authors Barbosa, D H X, Gondim, C R, Silva-Henriques, M Q, Soares, C S, Alves, D N, Santos, S G, Castro, R D
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Instituto Internacional de Ecologia 2023
Subjects
Antifungal Agents - pharmacology
antifungals
Biofilms
BIOLOGY
Candida
candidiasis
Coriandrum
essential oil
medicinal plants
Microbial Sensitivity Tests
Oils, Volatile - pharmacology
Plankton
antifúngicos
candidíase
óleo essencial
plantas medicinais
antifungals
essential oil
candidiasis
medicinal plants
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Summary:This study aimed to analyze the phytochemical profile of essential oil obtained from the leaves of Coriandrum sativum L., and its antifungal activity against Candida spp. The research consisted of an in vitro study including collecting the vegetable product, analysis of its macronutrients, extraction, and chemical analysis of the essential oil, and assaying antifungal activity through minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), with growth inhibition kinetics, and the product's effects on multi-species Candida biofilm. Nitrogen (47.08 g Kg-1), phosphorus (5.3 g Kg-1) and potassium (50.46 g Kg-1) levels were within the normal range. The major constituents were octanal, decanal, dec-(2E)-enal, and dodecanal. The MIC and MFC of the product evaluated against 11 tested Candida strains ranged from 31.25 to 250 μg/mL. There was inhibition of fungal growth during 24 hours of exposure at the 3 concentrations tested (250, 125, and 62.5 μg/mL). The concentration of 80 mg/mL promoted the greatest reduction in multispecies biofilm (70% reduction in biofilm). Coriandrum sativum L. essential oil extract is principally constituted of alcohols and aldehydes and presents fungicidal activity against Candida spp. in its in planktonic and biofilm forms.
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ISSN:1678-4375
1678-4375
DOI:10.1590/1519-6984.264875