INFLAMMATION ROLE AND ANTI-INFLAMMATORY STRATEGIES IN ACUTE CARDIOVASCULAR PATHOLOGY

In patients with myocardial infarction, the dynamics of acute phase proteins (APP), oxidative stress and white blood cell functional activity was investigated. A statistically significant increase in APP levels was observed starting from Day 1, reached its peak at Day 7, and disappeared by Day 28. A...

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Bibliographic Details
Published inRossiĭskiĭ kardiologicheskiĭ zhurnal no. 5; pp. 30 - 34
Main Authors I. I. Chukaeva, N. V. Orlova, F. A. Evdokimov, V. A. Aleshkin, O. O. Soloshenkova, L. I. Novikova, N. P. Rechnova
Format Journal Article
LanguageRussian
Published FIRMA «SILICEA» LLC 01.10.2009
Subjects
ace inhibitors
acute phase proteins
inflammation
myocardial infarction prognosis
oxidative stress
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Summary:In patients with myocardial infarction, the dynamics of acute phase proteins (APP), oxidative stress and white blood cell functional activity was investigated. A statistically significant increase in APP levels was observed starting from Day 1, reached its peak at Day 7, and disappeared by Day 28. Acute phase parameters correlated with oxidative stress characteristics. APP levels were higher in patients with more severe clinical course. The rate of haptoglobin concentration reduction was higher in participants receiving ACE inhibitors, comparing to the control group. Therefore, ACE inhibitor therapy might affect inflammation and sclerosis processes in the infarction area.
ISSN:1560-4071
2618-7620