Mitoprotective effect of the receptor antagonist interleukin-1 in experimental cerebral stroke

Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats. Against a background of RAIL-1 administration significant stabilization of mitochondria f...

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Bibliographic Details
Published inPatolohii͡a no. 3; pp. 71 - 75
Main Author E. V. Suprun
Format Journal Article
LanguageEnglish
Published Zaporozhye State Medical University 01.12.2012
Subjects
experimental cerebral ischemia
IL-1
mitochondrial pore
RAIL-1
thiol-disulfide system
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Summary:Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats. Against a background of RAIL-1 administration significant stabilization of mitochondria functional activity was noted (by blocking of mitochondrial pore opening) as wel as the state of thiol-disulfide system: normalization of activity of glutationperoxidase and glutationreductase, increase of levels of reduced forms of glutathione and thiols against a background of reduction of their oxidized forms. By mitochondrial activity RAIL-1 can be compared to Thiotriazoline and even exceeds it in some parameters.
ISSN:2306-8027
2310-1237
DOI:10.14739/2310-1237.2012.3.17019