Influence of ligand structure on anticancer and antioxidant properties of rhenium cluster compounds

Under the model growth of T8 Guerin’s carcinoma in rats we studied the anticancer activity of the system rhenium-platinum, which includes cis-dicarboxylates of rhenium (III) with different alkyl ligands, erythrocytes number and its morphological structure, erythrocytic stability, blood haemoglobin c...

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Published inVisnyk Dnipropetrovsʹkoho universytetu. Serii͡a︡ biolohii͡a︡, ekolohiia Vol. 17; no. 3; pp. 46 - 53
Main Authors I. V. Leus, E. D. Skorik, N. V. Beztsinna, N. I. Shtemenko
Format Journal Article
LanguageEnglish
Russian
Published Oles Honchar Dnipropetrovsk National University 01.11.2009
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Summary:Under the model growth of T8 Guerin’s carcinoma in rats we studied the anticancer activity of the system rhenium-platinum, which includes cis-dicarboxylates of rhenium (III) with different alkyl ligands, erythrocytes number and its morphological structure, erythrocytic stability, blood haemoglobin concentration, catalase activity and concentration of TBA-active products in the rats blood plasma. The renium-platinum system had considerable antioxidat effect and prevented the growth of tumour, that was maximal for a compound with the pivalate ligand.
ISSN:2310-0842
2312-301X
DOI:10.15421/010966