New approach to heart rate control as mortality reduction method in cardiac patients: potential of a new If inhibitor, ivabradine

Large-scale epidemiological studies have demonstrated that heart rate (HR) is an independent risk factor, increasing total, sudden and cardiovascular mortality risk. Ivabradine specifically binds to sinus node (SN) f-channels and reduces HR. Due to its specific SN action and selective If current inh...

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Published inKardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika Vol. 6; no. 6; pp. 58 - 68
Main Authors Yu. B. Belousov, O. A. Maneshina, S. B. Erofeeva
Format Journal Article
LanguageRussian
Published SILICEA-POLIGRAF» LLC 01.12.2007
Subjects
f-каналы
ивабрадин
ионные токи if
ишемическая болезнь сердца
сердечно-сосудистая смертность
стабильная стенокардия
частота сердечных сокращений
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Summary:Large-scale epidemiological studies have demonstrated that heart rate (HR) is an independent risk factor, increasing total, sudden and cardiovascular mortality risk. Ivabradine specifically binds to sinus node (SN) f-channels and reduces HR. Due to its specific SN action and selective If current inhibition, ivabradine dose-responsively reduces HR at rest and maximal physical exertion, without changes in mean blood pressure. It has been shown that ivabradine is not only well-tolerated, but also possesses anti-anginal and anti-ischemic effects, as potent as those for modern angina treatment agents: beta-blockers and calcium antagonists.
ISSN:1728-8800
2619-0125