Establishment and Verification of Reference Interval of Serum Prolactin in Healthy Single Pregnant Women of Childbearing Age in Suzhou, China

• Published in: Xiehe Yixue Zazhi Vol. 16; no. 2; pp. 393 - 398
• Main Authors: SUN Fangcan, LI Li, LI Xiaoyu, ZHOU Jinhua, HAN Bing
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Medical Journal of Peking Union Medical College Hospital 29.03.2025
• Subjects: gestation period; pregnant women; prolactin; reference interval
• ISSN: 1674-9081
• DOI: 10.12290/xhyxzz.2024-0339

Objective To analyze serum prolactin (PRL) levels during pregnancy in healthy single pregnant women of childbearing age in Suzhou, and to establish and verify the reference interval of serum PRL. Methods From January to March, 2022, the data of pregnant women with healthy single pregnancy at childbearing age were collected and prospectively followed up until delivery. According to the gestational age, the subjects were divided into early pregnancy group (less than 14 weeks), middle pregnancy group (14-27+6 weeks) and late pregnancy group (≥28 weeks). PRL was determined by Soling LIAISON XL automatic chemiluminescence immunoassay and LIAISON® prolactin. After eliminating outliers, the medical reference interval of serum PRL during pregnancy was established by percentile method (P2.5-P97.5). In addition, 20 samples of healthy single pregnant women of childbearing age were randomly collected in early, middle and late pregnancy to verify the established reference interval. When no more than two PRL measurements i