Pharmaco-EEG of antipsychotics’ response: a systematic review

• Published in: European psychiatry Vol. 67; no. S1; pp. S669 - S670
• Main Authors: De Pieri, M, Rochas, V, Sabe, M, Michel, C, Kaiser, S
• Format: Journal Article
• Language: English
• Published: Paris Cambridge University Press 01.08.2024
• Subjects: Biomarkers; Electroencephalography; Systematic review
• ISSN: 0924-9338; 1778-3585
• DOI: 10.1192/j.eurpsy.2024.1391

IntroductionResponse to antipsychotic medications (AP) is subjected to a wide and unpredictable variability and efforts were directed to discover predictive biomarkers to personalize treatment. Electroencephalography abnormalities in subjects with schizophrenia were reported, as well as a pattern of EEG changes induced by APsObjectivesThe aim of this review is to provide a synthesis of the EEG features that are related to APs efficacy, including both pre-treatment signatures and changes induced by APs during treatment.MethodsA systematic review of English articles using PubMed, PsychINFO and the Cochrane database of systematic reviews was undertaken in april 2023. Additional studies were added by hand-search. Studies having as an endpoint the relationship between AP-related clinical improvement and electroencephalographic features were included. Heterogeneity prevented a quantitative synthesis.ResultsOut of 1232 records screened, 22 studies were included in a final qualitative synthesis. Included studies evaluated resting-state and task-related power spectra, functional connectivity, microstates and epileptic abnormalities. At pre-treatment EEG, the most relevant predictors of a poor response were a change in theta power compared to healthy control, a high alpha power and connectivity, a diminished beta power in resting-state. Considering EEG during treatment, an increased theta power, a reduced beta-band activity, an increased alpha activity, a decreased coherence in theta, alpha and beta-band were related to a favorable outcome.ConclusionsEEG is promising as a method to create a predictive biomarker for response to APs; further investigations are warranted to harmonize and generalize the contradictory results of reviewed studies.Disclosure of InterestNone Declared