Lymphovascular Invasion is a Significant Prognostic Marker of Distant Metastasis in Breast Carcinoma

Lymphovascular invasion (LVI) is not incorporated in most staging systems although assessment of LVI is now part of the minimum data set for breast carcinoma pathology reporting. This study investigates the correlation between LVI with clinical staging, grading and prediction of patients’ survival i...

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Bibliographic Details
Published inOnline journal of health & allied sciences : OJHAS Vol. 17; no. 2
Main Authors Nor Haizura Abd Rani, Reena Rahayu Md. Zin, Ahmad Toha Samsudin, Chuah Jitt Aun
Format Journal Article
LanguageEnglish
Published Light House Polyclinic Mangalore 01.07.2018
Subjects
Grading
Invasive breast carcinoma
Lymphovascular invasion
Prognosis
Staging
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Summary:Lymphovascular invasion (LVI) is not incorporated in most staging systems although assessment of LVI is now part of the minimum data set for breast carcinoma pathology reporting. This study investigates the correlation between LVI with clinical staging, grading and prediction of patients’ survival in patients with invasive breast carcinoma. This was a retrospective study using data obtained from reviewing archival histological material and patients’ medical records at Queen Elizabeth Hospital, Sabah, Malaysia. Breast carcinoma samples from 117 female patients at all stages of disease were included in this study. Correlation was performed between LVI and staging, grading, lymph node (LN) status and patient’s clinical outcome after five years of diagnoses. LVI showed significant correlation with LN involvement and distant metastasis but no significant correlation between LVI and grading. LVI correlates with clinical staging and is a reliable predictor of outcome in patients with invasive breast carcinoma.
ISSN:0972-5997
0972-5997