Clinicopathological Spectrum of Schwannoma – A 3-year Retrospective Study with Emphasis on Unusual Sites

• Published in: Online journal of health & allied sciences : OJHAS Vol. 22; no. 2
• Main Authors: Nithya Roopa Prem, Swati Sharma, Kanthilatha Pai, Mary Mathew
• Format: Journal Article
• Language: English
• Published: Light House Polyclinic Mangalore 01.07.2023
• Subjects: benign; neural; schwann cells; schwannoma
• ISSN: 0972-5997

Introduction: Schwannoma is a benign neoplasm of neural origin, commonly associated with cranial nerves. The aim of the study is to study the spectrum of demographic and clinical presentation of this neoplasm with special emphasis on unusual sites. We also discuss the histopathological features at these sites and analyse these with the available literature. Materials and Methods: This is a retrospective cross-sectional study of 3 years, where all diagnosed cases of Schwannoma at unusual sites were studied for histopathological parameters along with the clinical and radiological details. Results: 18 cases of Schwannoma at unusual locations were analysed. The age range was 20-82 years with mean age being 45.5 years. The sex ratio was equal. The most common presenting symptom was painless swelling with a duration ranging from 5 days to 7 months. Mean size was 4 cm. The most common site was the head and neck region and lower limbs constituting 28% cases each. All patients underwent complete surgical excision. Clinico-histopathological correlation was 70%. Histopathology confirmed the diagnosis in all cases. Conclusion: Schwannomas are benign lesions with good prognosis and minimal chance of malignant progression. However, the unusual sites and misleading presentations may pose diagnostic challenge for both the clinicians and pathologists alike. The lack of awareness of occurrence of this benign entity at unusual location may lead to unnecessary treatment. Pathologists should keep Schwannoma as a differential diagnosis even if the lesion is present at unusual site.