A Study of Clinical Profile and Spontaneous Course of Eosinophilia

Aim of the study was evaluation of symptoms and signs in patients with eosinophilia, to try to find itsetiology and to study the natural course of eosinophilia during the period of study. Fifty patients withabsolute eosinophil count (AEC) more than 350/mm3 or differential count more than 3% irrespec...

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Published inJK science : journal of medical education and research Vol. 7; no. 4; pp. 199 - 201
Main Author Anshu Makkar, Anurag Rohtagi, Atul Goel, S. K. Sharma, Sandeep Garg, Shashi Narayan, Renu Dutta
Format Journal Article
LanguageEnglish
Published Dr. Annil Mahajan 01.10.2005
Subjects
Eosinophilia
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Summary:Aim of the study was evaluation of symptoms and signs in patients with eosinophilia, to try to find itsetiology and to study the natural course of eosinophilia during the period of study. Fifty patients withabsolute eosinophil count (AEC) more than 350/mm3 or differential count more than 3% irrespectiveof their age, sex and medical condition were included. The patients were divided into mild (AEC-350to 1500), moderate (1500 to 5000) and severe (>5000/mm3 of blood) eosinophilia. They underwent aseries of routine and special hematological and biochemical investigations including bone marrowaspiration, serum IgE estimation, and pulmonary function tests. The patients were studied for aperiod of 3 months. Most of the patients (52%) fell in the category of mild eosinophilia. MinimumAEC at the entry of patients into the study was 600 and maximum was 22500. Commonest presentingsymptoms were anorexia (40%), pain abdomen (38%), fever (32%), and breathlessness (30%).Etiology of eosinophilia was undiagnosed in 70% of the patients. Parasitism was more common thanallergic rhinitis and bronchial asthma. On follow up investigations, eosinophilia resolved on its own evenwithout specific antieosinophilic treatment. Extensive work up of patients was not associated with significantchange in the management of any patients with eosinophilia. The etiology of eosinophilia remains unrevealedin majority of the patients. Extensive work up of patients with eosinophilia is not recommended.
ISSN:0972-1177