The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer

• Published in: Majallah-i Dānishgāh-i ʻUlūm-i Pizishkī̄-i Bābul Vol. 23; no. 1; pp. 386 - 392
• Main Authors: M Zorriye Mahmoud, S Ghaffarian, M Valipour, N Pouladi, V Montazeri
• Format: Journal Article
• Language: English
• Published: Babol University of Medical Sciences 01.03.2021
• Subjects: association evaluation; breast cancer; erbb4 gene; single nucleotide polymorphism
• ISSN: 1561-4107; 2251-7170

BACKGROUND AND OBJECTIVE: Breast cancer is the most common cancer in women and the leading cause of cancer death in women worldwide. The ERBB4 gene, a member of the tyrosine kinase family, has been identified as both a tumor suppressor and an oncogene in breast cancer. In this study, the association between rs1972820G>A polymorphism of ERBB4 gene and the risk of breast cancer in northwestern Iran was investigated. METHODS: This case-control study was performed on 89 women with breast cancer and 98 healthy women with no family history of cancer. Clinical characteristics of patients included age (less than, greater than or equal to 49 years and unknown), involved side (right, left, both and unknown), type of tumor (ILC, IDC, other types and unknown), tumor grade (I, II or III), tumor size (T1, T2, T3 and unknown) and lymph node involvement (N0, N1, N2, N3 and unknown). Single nucleotide polymorphisms were examined by TETRA-ARMS-PCR technique. FINDINGS: The genotypic distribution of sick and healthy individuals was 66% and 56% for AA genotype, 9% and 6% for GG genotype and 25% and 38% for AG genotype, respectively. The frequency of Allele A was 147 and 140 and the frequency of G Allele was 49 and 38 in patients and controls, respectively (p>0.05). CONCLUSION: The findings of this study showed that there is no significant relationship between genotypic and allelic distribution of rs1972820 polymorphism of ERBB4 gene with increased risk of breast cancer and clinical features of patients in northwestern Iran.