Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures

Background and objective: Hesperetin as the main flavonoid in citrus possesses various pharmacological properties including anti-oxidant and anti-inflammatory effects. In this study, the effects of hesperetin on seizures behavior and its function on total antioxidant capacity and lipid peroxidation...

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Published inMajallah-i Dānishgāh-i ʻUlūm-i Pizishkī̄-i Bābul Vol. 20; no. 11; pp. 19 - 26
Main Authors S Baradaran, M Ghasemi-Kasman, A Ebrahimpour, SR Ahmadian, M Pouramir
Format Journal Article
LanguageEnglish
Published Babol University of Medical Sciences 01.11.2018
Subjects
Convulsion
Hesperetin
Pentylenetetrazol
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Summary:Background and objective: Hesperetin as the main flavonoid in citrus possesses various pharmacological properties including anti-oxidant and anti-inflammatory effects. In this study, the effects of hesperetin on seizures behavior and its function on total antioxidant capacity and lipid peroxidation has been investigated in pentylenetetrazol (PTZ)-induced seizures model. Materials and methods: In this experimental study, thirty-five mice were divided into 5 experimental groups as control, saline and hesperetin at doses of 10, 20 or 50 mg/kg. Animals received orally the related interventions for 7 days. On day 7, 30 minutes after oral gavage, convulsion was induced by single intraperitoneal (i.p.) injection of PTZ at dose of 60 mg/kg. After recording of convulsion behaviors including latency to myoclonic jerks, latency and duration of generalized tonic-clonic seizures, time to death, measuring of Ferric Reducing Antioxidant Power (FRAP) and Thiobarbituric acid reactive substances (TBARS) carried out in hippocampus tissues. Findings: Pretreatment with hesperetin at dose of 50 mg/kg significantly increased the latency of myoclonic jerks (hesperetin 50: P=0.0323) and generalized tonic-clonic seizures (hesperetin 10: P= 0.0003, hesperetin 20: 0.0017, hesperetin 50: P=0.0040). Hesperetin application at dose of 10 mg/kg significantly reduced the levels of TBARS compared to control group. Any significant difference in FRAP levels was not observed between different experimental groups. Conclusion: The results of study indicate that hesperetin might be effective as supplementary treatment in epilepsy disorder.
ISSN:1561-4107
2251-7170