The Expression of MicroRNA-155 (miR-155) and Carcinoembryonic Antigen Messenger RNA (CEA mRNA) in Peripheral Blood of Patients with Oral Squamous Cell Carcinomas (OSCC)

• Published in: Majallah-i dānishkadah-i pizishkī-i Iṣfahān. (Online) Vol. 36; no. 510; pp. 15597 - 1601
• Main Authors: Armita Narimani, Farzaneh Hosseini, Naghmeh Bahrami, Abdolreza Mohamadnia
• Format: Journal Article
• Language: Persian
• Published: Isfahan University of Medical Sciences 01.03.2019
• Subjects: Carcinoembryonic antigen; Early diagnosis; Head and neck squamous cell carcinoma; MicroRNAs; mRNA
• ISSN: 1027-7595; 1735-854X
• DOI: 10.22122/jims.v36i510.10925

Background: Oral squamous cell carcinoma (OSCC) accounts for about 90% of all malignant oral tumors, and is often diagnosed in advanced stages. In this study, changes in the expression of microRNA-155 (miR-155) and carcinoembryonic antigen messenger RNA (CEA mRNA) in peripheral blood of patients with oral cancer were investigated. Methods: In this study, 30 patients and 30 healthy people were selected. The miR-155 and CEA mRNA levels in their peripheral blood were measured and evaluated using real-time polymerase chain reaction (real-time PCR) technique. Findings: Positive miR-155 marker was observed in 21 people from 30 with oral cancer, and 7 of 30 healthy subjects. The CEA mRNA marker was positive in 23 of the 30 patients, and 5 out of 30 healthy subjects. Conclusion: In sum, the outcome of this study can be seen as a screening diagnostic test for early detection of the disease in the early stages.