Efficacy of polyprenyl phosphates in the experimental genital herpes model

• Published in: Voprosy virusologiĭ Vol. 60; no. 4; pp. 9 - 13
• Main Authors: Narovlyansky, A N, Ivanova, A M, Shevlyagina, N V, Didenko, L V, Borovaya, T G, Izmest'eva, A V, Sanin, A V, Pronin, A V, Ershov, F I
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) Central Research Institute for Epidemiology 2015
• Subjects: acyclovir; Acyclovir - pharmacology; Animals; Antiviral Agents - pharmacology; Disease Models, Animal; Female; guinea pig ovary; Guinea Pigs; Herpes Genitalis - drug therapy; Herpes Genitalis - metabolism; Herpesvirus 2, Human - metabolism; Humans; Polyisoprenyl Phosphates - pharmacology; polyprenyl phosphates; recurrent genital herpes
• ISSN: 0507-4088; 2411-2097

An experimental model of the primary genital herpes (herpes simplex type 2, HSV-2) in the female guinea pigs was suggested to study the infectious process activity of polyprenyl phosphates (PPP) and PPP+acyclovir (AC) complex treatment. The morphofunctional features of the guinea pig ovaries were studied in the control and experimental groups (the latter were inoculated with PPP and/or AC as a primary infection treatment) at the stage of the recurrent genital herpes aggravation. It was shown that in the case of combined PPP +AC use significant changes in the disease symptoms were observed, as well as a decrease in the infectious process activity and duration, and positive remote effect on the ovarian morphophysiology.