Effect of red maca (Lepidium meyenii) on INF-γ levels in ovariectomized rats

Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and...

Full description

Saved in:
Bibliographic Details
Published inRevista peruana de medicina experimental y salud pública Vol. 31; no. 4; pp. 683 - 688
Main Authors Leiva-Revilla, Johanna, Guerra-Castañon, Félix, Olcese-Mori, Paola, Lozada, Iván, Rubio, Julio, Gonzales, Carla, Gonzales, Gustavo F
Format Journal Article
LanguageSpanish
Published Peru Instituto Nacional de Salud 01.10.2014
Subjects
Animals
estradiol
Female
Interferon-gamma - blood
Interferon-gamma - drug effects
interferón gamma
Lepidium
maca
Ovariectomy
ovariectomía
Plant Extracts - pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
Online AccessGet full text

Cover

More Information
Summary:Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Red maca administration increases levels of IFN-γ in ovariectomized rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1726-4634
1726-4642
DOI:10.17843/rpmesp.2014.314.118