Transplacental IgG against measles virus in umbilical blood of neonates from various regions of Russian Federation

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii Vol. 92; no. 1; pp. 52 - 57
• Main Authors: Shmit'ko, A D, Kostinov, M P, Bocharova, I I, Savis'ko, A A, Magarshak, O O, Polishchuk, V B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) Central Research Institute for Epidemiology 01.01.2015
• Subjects: Adolescent; Adult; antibodies against measles; Antibodies, Viral - immunology; Antibodies, Viral - isolation & purification; antibody avidity; Female; Fetal Blood - immunology; Fetal Blood - virology; Humans; Immunoglobulin G - isolation & purification; Infant, Newborn; measles; Measles - immunology; Measles - prevention & control; Measles - virology; Measles Vaccine; Measles virus - immunology; Measles virus - isolation & purification; neonates; Pregnancy; Russia; transplacental igg; umbilical blood; Vaccination; Russia
• ISSN: 0372-9311; 2686-7613

Determine content of protective transplacental IgG against measles virus in umbilical blood of neonates of various regions of Russian Federation. Umbilical blood of 1147 neonates was studied, whose mothers had not previously had measles. 672 samples among those were from neonates of Moscow and Moscow Region, 475--from Rostov-on-Don. IgG values were determined in EIA using a standard kit from "Vector Best" (VectoKor-IgG). A kit from Euroimmun--Avidity: Anti-Measles Virus ELISA (IgG) was used for determination of avidity of IgG against measles virus. Protective (≥ 0.18 IU/ml) IgG against measles were registered in 79.9% of children in Moscow, Moscow Region and in 81.3% of neonates in Rostov-on-Don. Mean level of IgG in umbilical blood sera of neonates from the studied regions was within protective values (1.74 ± 0.13 IU/ml and 1.51 ± 0.09 IU/ml, respectively). Predominance of low level antibodies was noted in the studied samples (< 1.0 IU/ml), those are highly avid though (AI > 60%). In neonates from women aged 16 - 25 years in Moscow and Moscow Region protective antibodies were detected in 83.6%; 26 - 35 years--in 75%; women aged 36 - 43 years--in 88.2% of cases. Mean level of IgG in umbilical blood of neonates from mothers aged 36 - 43 years was 1.5 times higher than from mothers aged 16 - 25 years and 2 times higher than mothers 26 - 35 years of age. Neonates from Moscow, Moscow Region and Rostov-on-Don, similarly, in 79.9% and 81.3% of cases are protected from measles, respectively. Women aged 26-35 years in 25% of cases are a risk group for measles morbidity and require a closer attention during selection of vaccination tactics before conception, and their neonates--on reaching decree terms.