Prevalence of allergic diseases in children with secondary renal tubular acidosis attending a tertiary care pediatric center

• Published in: Revista alergia Mexico (Tecamachalco, Pueblo, Mexico : 1993) Vol. 64; no. 2; pp. 133 - 141
• Main Authors: Morfín-Maciel, Blanca María, García-De la Puente, Silvestre, Bojórquez-Ochoa, Aurora, Huante-Anaya, Alfonso, Orozco-Martínez, Socorro, Zaltzman-Girshevich, Samuel, Guzmán-Vázquez, Elizabeth
• Format: Journal Article
• Language: Spanish; English
• Published: Mexico Colegio Mexicano de Inmunología Clínica y Alergia, A.C 01.04.2017
• Subjects: Acidosis tubular renal secundaria; Acidosis, Renal Tubular - blood; Acidosis, Renal Tubular - epidemiology; Acidosis, Renal Tubular - etiology; Adolescent; Bicarbonates - blood; Bicarbonato sérico; Child, Preschool; Comorbidity; Cross-Sectional Studies; Enfermedades alérgicas; Female; Food Hypersensitivity - diagnosis; Food Hypersensitivity - epidemiology; Hospitals, Pediatric - statistics & numerical data; Humans; Hypersensitivity - blood; Hypersensitivity - diagnosis; Hypersensitivity - epidemiology; Immunoglobulin E - blood; Infant; Male; Mexico - epidemiology; Niños; Prevalence; Prospective Studies; Skin Tests; Tertiary Care Centers - statistics & numerical data; Mexico; Serum bicarbonate; Allergic diseases; Children; Secondary renal tubular acidosis
• ISSN: 0002-5151; 2448-9190
• DOI: 10.29262/ram.v64i2.226

It has been suggested a high prevalence of allergic disease in children with RTA. To describe the prevalence of allergic diseases in children with secondary RTA (renal tubular acidosis) in the nephrology department of the National Institute of Pediatrics (NIP), México. An observational, prospective, cross-sectional, descriptive study. Children with secondary RTA < 18 years who attended the outpatient nephrology service in the NIP for 24 months, were included. ISAAC questionnaire and the EAACI guidelines were applied. To prove a suspected allergy, skin tests, total and specific IgE, patch testing and food challenge were performed. Using SPSS 19, frequency of allergic diseases was described. 113 patients were included. Age 8 to 168 months. Male: 53.9 %. RTA types: Distal (64.6 %), proximal (26.5 %), mixed (1.8 %) and undetermined (7 %). Age of onset between 1 and 96 months. Serum bicarbonate 10.1 to 20 mEq/L. Allergic diseases were found in 24.8 %: allergic rhinitis (18.4 %), food allergy (9.7 %), atopic dermatitis (8 %), asthma (8 %) and allergic conjunctivitis (6.1 %). Total IgE was increased in 9 patients. Positive skin tests in 14.2 %. Positive chemiluminescence in 18 children; positive open food challenge in 11 children and patch tests in 4. Secondary RTA is common in children attending tertiary care hospitals. The prevalence of allergic disease in children with secondary ATR, is similar to that described in the general population.