Clinical symptoms in IgA deficiency

IgA deficiency is the most common primary immunodeficiency. Early diagnosis and clinical follow-up may improve the quality of life of patients with IgA deficiency. To this end, IgA deficiency should be further studied and better understood on its clinical manifestations. To determine IgA deficiency...

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Published inRevista alergia Mexico (Tecamachalco, Pueblo, Mexico : 1993) Vol. 64; no. 1; pp. 34 - 39
Main Authors De Oliveira-Serra, Flavio Augusto, Mosca, Tainá, Santos de Menezes, Maria da Conceição, Carvalho-Neves Forte, Wilma
Format Journal Article
LanguageEnglish
Spanish
Published Mexico Colegio Mexicano de Inmunología Clínica y Alergia, A.C 01.01.2017
Subjects
Adolescent
Adult
Asthma - etiology
Child
Child, Preschool
Conjunctivitis, Allergic - etiology
Cross-Sectional Studies
Deficiencia de anticuerpos
Deficiencia de inmunoglobulina A
Dimerization
Early Diagnosis
Female
Humans
IgA Deficiency - complications
IgA Deficiency - diagnosis
Immunoglobulin A - chemistry
Inmunodeficiencias primarias
Male
Retrospective Studies
Rhinitis - etiology
Symptom Assessment
Tonsillitis - etiology
Young Adult
Antibody deficiency
IgA deficiency
Primary immunodeficiency
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Summary:IgA deficiency is the most common primary immunodeficiency. Early diagnosis and clinical follow-up may improve the quality of life of patients with IgA deficiency. To this end, IgA deficiency should be further studied and better understood on its clinical manifestations. To determine IgA deficiency clinical manifestations. Cross-sectional, retrospective, exploratory study, where the medical records of 39 patients with IgA deficiency were analyzed. Among the analyzed cases, 10 patients were diagnosed with total IgA deficiency and 29 patients with partial IgA deficiency. Partial and total IgA deficiency main clinical manifestations were allergic rhinoconjunctivitis and allergic asthma. In total IgA deficiency, in addition to allergic diseases, a statistically significant number (p < 0.05) of cases of infection-related rhinosinusitis, tonsillitis and conjunctivitis were also observed. This study showed that the main clinical manifestations in IgA deficiency were allergic rhinoconjunctivitis and allergic asthma. In addition, patients with total IgA deficiency showed a significant increase in infection-related rhinosinusitis, tonsillitis and conjunctivitis, when compared with patients with partial IgA deficiency.
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ISSN:0002-5151
2448-9190
DOI:10.29262/ram.v64i1.216