3D printing of pearl/CaSO 4 composite scaffolds for bone regeneration

The development of biomaterials with high osteogenic ability for fast osteointegration with a host bone is of great interest. In this study, pearl/CaSO composite scaffolds were fabricated using three-dimensional (3D) printing, followed by a hydration process. The pearl/CaSO scaffolds showed uniform...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 6; no. 3; pp. 499 - 509
Main Authors Du, Xiaoyu, Yu, Bin, Pei, Peng, Ding, Huifeng, Yu, Baoqing, Zhu, Yufang
Format Journal Article
LanguageEnglish
Published England 21.01.2018
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Summary:The development of biomaterials with high osteogenic ability for fast osteointegration with a host bone is of great interest. In this study, pearl/CaSO composite scaffolds were fabricated using three-dimensional (3D) printing, followed by a hydration process. The pearl/CaSO scaffolds showed uniform interconnected macropores (∼400 μm), high porosity (∼60%), and enhanced compressive strength. With CaSO scaffolds as a control, the biological properties of the pearl/CaSO scaffolds were evaluated in vitro and in vivo. The results showed that the pearl/CaSO scaffolds possessed a good apatite-forming ability and stimulated the proliferation and differentiation of rat bone mesenchymal stem cells (rBMSCs), as well as giving a better expression of related osteogenic genes. Importantly, micro-computed tomography and histology of the critical-sized rabbit femoral condyle defects implanted with the scaffolds illustrated the osteogenic capacity of the pearl/CaSO scaffolds. New bone was observed within 8 weeks. The bone-implant contact index was significantly higher for the pearl/CaSO scaffolds implant than for the CaSO scaffolds implant, indicating that the pearl/CaSO scaffolds would be promising implants for bone regeneration.
ISSN:2050-750X
2050-7518
DOI:10.1039/C7TB02667F