Seroconversion Studies of Indian Newcastle Disease Virus Isolates of Genotype XIII in 3 week Old Chickens

• Published in: Biosciences, biotechnology research Asia Vol. 16; no. 1; pp. 27 - 31
• Main Authors: Jakhesara, S. J., Patel, A. K., Malsaria, Priya, Pal, J. K., Joshi, C.G.
• Format: Journal Article
• Language: English
• Published: Bhopal Biosciences Biotechnology Research Asia 28.03.2019
• Subjects: Antibodies; Antigens; Birds; Chickens; Disease; Economic impact; Economics; Genotype & phenotype; Genotypes; Immunoglobulins; Newcastle disease; Outbreaks; Poultry; Seroconversion; Strains (organisms); Vaccines; Virology; Viruses; India
• ISSN: 0973-1245; 2456-2602
• DOI: 10.13005/bbra/2717

Poultry industry plays an important role in sustaining economy of India. Despite routine vaccination strategies has been a common practice to control commonly occurring diseases in poultry, outbreaks are commonplace. Recently, emergence of genotype XIII strains of NDV resulted in widespread economic losses in India. We prepared inactivated oil adjuvant vaccine derived from Lasota, ndv53/Haryana or ndv52/Sarsa, which is recently isolated genotype XIII virus in India. Three groups of SPF chickens were vaccinated once with each vaccine and serum samples were collected every 7 days interval and tested for HI titres with three different antigens prepared from same virus to assess cross neutralization antibodies amongst them. All three vaccines have shown some degree of cross reactivity after 14 days post vaccination. However, vaccine prepared from Lasota, a genotype II virus failed to generate significant titers against both ndv53/Haryana and ndv52/Sarsa. Our observation explains recent outbreaks of genotype XIII viruses in the field and necessitates development of new vaccines to control the recently emerged NDV strains in India.