Lipid sensing by gut CD1d calibrates peripheral serotonin release

Abstract The crosstalk between the immune and the neuroendocrine system is critical for intestinal homeostasis and gut-brain communications. However, it remains unclear how immune cells participate in gut sensation of hormones release in response to environmental cues, such as self and microbial lip...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 210; no. 1_Supplement; pp. 150 - 150.07
Main Authors Wu, Chuan, Luo, Jialie, Chen, Zuojia, Castellano, David, Han, Wenyan, Lu, Wei, Li, Jian, Kim, Girak
Format Journal Article
LanguageEnglish
Published 01.05.2023
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Summary:Abstract The crosstalk between the immune and the neuroendocrine system is critical for intestinal homeostasis and gut-brain communications. However, it remains unclear how immune cells participate in gut sensation of hormones release in response to environmental cues, such as self and microbial lipids. We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promotes peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis. CD1d ligation on EC cells transduces a reverse signal and restrains potassium conductance, leading to calcium influx and 5-HT secretion. Together, we show that by coupling with iNKT cells, gut chemosensory cells perceive lipid antigens via CD1d to calibrate 5-HT release, modulating intestinal and systemic physiology.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.210.Supp.150.07