Preventive Effects of Dietaryraisins on Steroid - Induced Bone Changes in Rats

Glucocorticoids is the most common cause of secondary osteoporosis. Osteoporosis is widespread, costly and causes pain, deformity and disability. Several studies report health benefits of raisins. Raisins have a combination of compounds with antibacterial, antioxidant,anticarcinogenic and anti-infla...

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Published inBiosciences, biotechnology research Asia Vol. 17; no. 4; pp. 809 - 817
Main Authors Aiman, Al-Qtaitat, Said, Al-Dalaien, Amal, Albtoosh, Karawya, Fardous
Format Journal Article
LanguageEnglish
Published Bhopal Biosciences Biotechnology Research Asia 15.01.2021
Subjects
Alkaline phosphatase
Animals
Anti-inflammatory agents
Antioxidants
Biochemical markers
Biomarkers
Biomedical materials
Bone marrow
Boron
Calcium
Calcium (blood)
Calcium (urinary)
Fractures
Glucocorticoids
Hydroxyproline
Inflammation
Metabolism
Methylprednisolone
Osteocalcin
Osteoporosis
Phosphatase
Polyphenols
Raisins
Steroids
Urine
Vertebrae
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Summary:Glucocorticoids is the most common cause of secondary osteoporosis. Osteoporosis is widespread, costly and causes pain, deformity and disability. Several studies report health benefits of raisins. Raisins have a combination of compounds with antibacterial, antioxidant,anticarcinogenic and anti-inflammatory properties. The present study investigated the impact of Raisins onmethylprednisolone-induced osteoporosis in rats. Thirty male albino rats were randomly divided into three main groups, ten rats each. Group I control group; Group II, osteoporotic group, where osteoporosis was induced by injection of methylprednisolone; Group III, protected group, animals were given raisinsconcomitant daily with methylprednisolone. Bone biochemical markers were assisted, hydroxyproline, urinary calcium excretion, serum calcium, alkaline phosphatase and osteocalcin. In addition to histological findings in lumbar vertebrae of the rats.Our findings showed that raisin has a positive osteoprotective effects on methylprednisolone induced bone changes histologically and over the biomarkers examined.This study suggests that dietary raisins may moderate methylprednisolone bone induced changes.
ISSN:0973-1245
2456-2602
DOI:10.13005/bbra/2886