Cross-coupling of [ 11 C]methyllithium for 11 C-labelled PET tracer synthesis

The cross-coupling of aryl bromides with [ C]CH Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of C (20.4 min)...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 2; pp. 203 - 206
Main Authors Helbert, Hugo, Antunes, Ines Farinha, Luurtsema, Gert, Szymanski, Wiktor, Feringa, Ben L, Elsinga, Philip H
Format Journal Article
LanguageEnglish
Published England 07.01.2021
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Summary:The cross-coupling of aryl bromides with [ C]CH Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of C-labelled compounds for PET imaging.
ISSN:1359-7345
1364-548X
DOI:10.1039/D0CC05392A