Photoredox catalyzed cascade CF 3 addition/chemodivergent annulations of ortho -alkenyl aryl ureas

Herein, we report a substrate-controlled cascade cyclization of -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versa...

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Published inChemical communications (Cambridge, England) Vol. 58; no. 12; pp. 1990 - 1993
Main Authors Babu, Sakamuri Sarath, Varma, A Anagha, Gopinath, Purushothaman
Format Journal Article
LanguageEnglish
Published England 08.02.2022
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Summary:Herein, we report a substrate-controlled cascade cyclization of -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives.
ISSN:1359-7345
1364-548X
DOI:10.1039/D1CC06289A