Clinico-biochemical and electrocardiographic changes in cattle naturally infected with lumpy skin disease
Lumpy skin disease (LSD) is an economically important viral disease of cattle caused by Capripox virus. The disease is characterized clinically by fever, nodules on the skin, mucous membranes and internal organs, emaciation, enlarged lymph nodes, edema of the skin and deaths in some cases. The aim o...
Saved in:
Published in | Alexandria Journal of Veterinary Sciences. Vol. 60; no. 1; pp. 41 - 48 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Alexandria, Egypt
Alexandria University, Faculty of Veterinary Medicine
2019
|
Online Access | Get full text |
Cover
Loading…
Summary: | Lumpy skin disease (LSD) is an economically important viral disease of cattle
caused by Capripox virus. The disease is characterized clinically by fever, nodules on the
skin, mucous membranes and internal organs, emaciation, enlarged lymph nodes, edema of
the skin and deaths in some cases. The aim of this study is to investigate the clinico-
biochemical picture of LSD infected cattle with special reference to the cardiac
abnormalities. This study was carried out on LSD infected cattle showing typical clinical
signs of the disease in Kaliobia governorate (n = 50; and aged between 2 to 5 years old).
Clinical and electrocardiographic examination (ECG) were performed firstly, then skin
nodules were aseptically collected from infected cattle for molecular detection of LSDV
using PCR, on the other hand, serum samples were collected for biochemical analysis. The
results of the current study revealed that, all the examined tissue samples showed successful
amplification of the viral attachment protein gene of LSDV with presence of positive bands
at the target size (192 bp). Furthermore, troponin I (cTnI), urea, creatinine ALT, AST, ALP
and potassium were significantly increased in LSD infected cattle compared to the control
ones. In contrast, serum calcium, iron and sodium concentrations were significantly
decreased. The ECG of LSD infected cattle showed abnormal P waves, shortening of P and
T-waves amplitudes and decrease in RT interval compared to healthy cattle. The cardiac
alterations in case of LSD infection could be related to the elevation of cTnI because of
direct effect of the virus on the heart beside electrolyte imbalance, acidosis and
hypocalcaemia. |
---|---|
ISSN: | 1110-2407 1110-2047 2536-9520 |
DOI: | 10.5455/ajvs.20434 |