Diastereoselective synthesis of CF 3 -dihydrobenzofurans by [4+1] annulation of in situ -generated CF 3 - o -quinone methides and sulfur ylides
An efficient and highly diastereoselective synthesis of CF -dihydrobenzofurans by the reaction of -generated CF - QMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding prod...
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Published in | RSC advances Vol. 10; no. 63; pp. 38588 - 38591 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
20.10.2020
|
Online Access | Get full text |
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Summary: | An efficient and highly diastereoselective synthesis of CF
-dihydrobenzofurans by the reaction of
-generated CF
-
QMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF
-
QM has been utilized first time for the annulation reaction. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/D0RA08289A |